BIRC5 and adenocarcinoma: Due to the unique role of BIRC5 in adenocarcinoma [27, 28] and its strongest negative correlation with PTPRT expression, we then focused on the influence of modulation of PTPRT expression on BIRC5. Notably, the protein levels of BIRC5 were decreased upon PTPRT overexpression in LUAD cells (Fig. 4A, B, Supplementary Fig. 1– 2), while the expression of BIRC5 was upregulated at both mRNA (Fig. 4C) and protein (Fig. 4D, Supplementary Fig. 3) levels upon PTPRT knockdown in multiple cell lines.