In a rabbit model of massive pulmonary embolism, sympathetic medium transmitters tyrosine hydroxylase and neuropeptide Y were upregulated in whole lung tissues, and intravenous sodium nitroprusside reduced mean pulmonary arterial pressure (mPAP) and treated cardiogenic shock by relieving vasospasms in both pulmonary embolism and non-pulmonary embolism areas. This evidence concerns the gene NPY and pulmonary embolism.