HRAS and neoplasm: To determine the antitumor activity of RGD-p21Ras-scFv in vitro, we used 30 μM PBS, RGD peptide, and 0.32 μM RGD-p21Ras-scFv with Ras-derived tumor cell lines (A549, AGS, AsPC-1, HePG-2, MDB-MA-321, MIApaca-2, PANC- 1, U 251, SW480, HT29 and SW480) and a normal colon epithelial cell line (CCD841) were co-cultured for a period of time, and cell proliferation was analyzed by CCK-8 assay.