It has been observed that similar genetic defects such as K-RAS activation and p53 loss in mouse non-small cell lung cancer (NSCLC) and pancreatic cancer cause a bifurcation of amino acid metabolism, indicating that metabolic reprogramming is dependent on the in-situ tissue (Mayers et al, 2016; Sullivan et al, 2019). This evidence concerns the gene TP53 and non-small cell lung carcinoma.