AKT1 and Wilson disease: As a result, the final mathematical model, which included only one diet-specific dynamic parameter, the basal MET phosphorylation rate, and 11 diet-specific parameters for protein abundance, was able to explain the increased basal phosphorylation and reduced maximal induction of pMET, pERK and pS6 as well as the reduced phosphorylation of AKT in response to HGF stimulation in WD hepatocytes (Fig. 3D).