DECR2 and posterior cortical atrophy: To investigate the mechanism by which PCa cell growth and proliferation was attenuated by knockdown of DECR2, we carried out genome-wide transcriptional profiling of V16D and MR49F PCa cells (n = 6 biological replicates for each) subjected to a pooled siRNA-mediated knockdown of DECR2 (Fig. 3a).