Next, we examined DECR2 protein expression in a panel of PCa cell lines: DECR2 levels were low in AR-positive, androgen-dependent LNCaP cells and AR-positive CRPC C42B cells, intermediate in AR-positive CRPC 22Rv1 cells, and high in AR-positive CRPC V16D and ENZ-resistant MR49F cell lines (Fig. 1h). This evidence concerns the gene AR and posterior cortical atrophy.