DECR2 and posterior cortical atrophy: Similarly, doxycycline (dox)-inducible knockdown of DECR2 with short hairpin RNA (shDECR2+Dox) significantly attenuated viability in LNCaP and 22Rv1 PCa cell lines (Fig. 2b; Supplementary Fig. 2d), but no effect was observed in dox-inducible control (shControl+Dox) cells (Supplementary Fig. 2c, d).