TKT and hepatocellular carcinoma: We extended our investigation to ascertain whether TKT regulates DSB repair in HCC cells by scrutinizing the kinetics of γH2AX induction following a 4 Gy X-Ray treatment in two HCC cell lines (Hep3B and HCCLM3) transfected with negative control siRNA (siCtrl) or siRNA against TKT (siTKT).