Some researchers studied the MAPK cascade activation and role in Chagas disease MEK/ERK pathway increase in nervous system models by the interaction of the host cells with surface molecules of T. cruzi as members of the multigene family of trans-sialidases45,46, while the inhibition of ERK1/2 phosphorylation produced a significant decrease in invasion and infection by this parasite in epithelial and cardiac muscle cells47 and in cultured human umbilical vein endothelial and vascular smooth muscle cells48. This evidence concerns the gene MAPK3 and Chagas disease.