Specifically, developmental CAFs (dCAFs), with high expression of MYH11 and MCAM, was functionally featured by muscle structure and tissue development (Fig. 3b, c and Supplementary Fig. 4b), and presented in both primary ccRCC and BMRCC (Fig. 3d and Supplementary Fig. 4c). The gene discussed is MCAM; the disease is nonpapillary renal cell carcinoma.