CD8-Tem1 that had higher expression of GZMB and CTSW were enriched in bone metastatic tumors, whereas CD8-Tem2 cells were enriched in primary ccRCC with higher expression of KLRD1, KLRF1, and KLRG1 (Fig. 4d and Supplementary Fig. 5c). Here, KLRF1 is linked to nonpapillary renal cell carcinoma.