We observed that MDSC-S100A12 and Macro-NLRP3, Macro-MRC1, Macro-CX3CR1, Macro-BAG3, Macro-CCL18, and Macro-NRP2 were enriched in the BMRCC, with primary ccRCC from early and late stages as comparison (Supplementary Fig. 6a, b). This evidence concerns the gene NLRP3 and nonpapillary renal cell carcinoma.