We observed that MDSC-S100A12 and Macro-NLRP3, Macro-MRC1, Macro-CX3CR1, Macro-BAG3, Macro-CCL18, and Macro-NRP2 were enriched in the BMRCC, with primary ccRCC from early and late stages as comparison (Supplementary Fig. 6a, b). Here, CX3CR1 is linked to nonpapillary renal cell carcinoma.