ICOS and nonpapillary renal cell carcinoma: Compared with primary ccRCC, we found specific receptor-ligand pairs between macrophages and immune-inhibitory T cells were enriched in BMRCC, including pro-migratory interaction (CCL4L2-VSIR), and immune-inhibitory interactions (SIRPA-CD47, LGALS9-HAVCR2, LGALS9-CD47, TNF-FAS and TNF-ICOS) (Fig. 7a).