The number of CD11b + P2ry12 + microglia remained unchanged, while the infiltration of CD11b + P2ry12− monocytes/macrophages and CD45highCD11b − P2ry12− lymphocytes into the inflamed brain was observed (Fig. 2B,C) 1 day after NMO-IgG injection. The gene discussed is ITGAM; the disease is neuromyelitis optica.