P2RY12 and neuromyelitis optica: While clodronate treatment did not alter microglia (CD11b + P2ry12+) and neutrophil (CD11b + Ly6c + Ly6G+), it selectively depleted monocyte (CD11b + Ly6C + Ly6G−) population in the CNS of NMO-like model (Fig. 3B,C).