Integrated single-nuclei and single-cell RNA sequencing showed PTPRG was expressed in schwannoma cells from human tumors (Fig. 2i), Perturb-seq suppression of PTPRG in schwannoma cells inhibited genes underlying nervous system development only in combination with radiotherapy (Fig. 2h), and CRISPRi suppression of PTPRG enhanced schwannoma cell apoptosis with radiotherapy (Fig. 2j and Supplementary Fig. 15g, h). This evidence concerns the gene PTPRG and schwannoma.