Comparison of tumor cell types in immune-enriched versus neural crest schwannomas showed enrichment of (1) immune-like schwannoma cells expressing BCL1 and CD74, a regulator of macrophage migration, axon repair, and survival of neural progenitor cells;23,24 (2) suppression of vascular remodeling schwannoma cells expressing ADGRB3, a regulator of angiogenesis and cell proliferation25–27, and (3) suppression of axon injury schwannoma cells expressing NRXN3, a regulator of synapse function28 (Fig. 1c, d). The gene discussed is ADGRB3; the disease is neoplasm.