Whole exome sequencing identified recurrent somatic short variants (SSVs) in the core PRC2 components SUZ12 or EED in Group 1 but not Group 2 or Group 3 histological neurofibromas and MPNSTs (Fig. 1a, Supplementary Fig. 2, and Supplementary Data 2). Here, EED is linked to plexiform neurofibroma.