NF1 and plexiform neurofibroma: To define the cellular architecture across groups of Schwann cell tumors, single-nuclear RNA sequencing was performed on 19,276 nuclei from Group 1 MPNSTs (n = 3) or Group 3 neurofibromas (n = 3) from patients with clinical diagnoses of NF-1 (Fig. 1c and Supplementary Fig. 4a).