In histological neurofibromas and MPNSTs across all 3 DNA methylation groups, CNVs deleting NF2 on chromosome 22q were enriched in Group 1 and Group 2 compared to Group 3 histologic neurofibromas or MPNSTs (60% versus 50% versus 11%, p = 0.02, Chi-squared test), typically in combination with NF1 or PRC2 alterations (Fig. 1a). This evidence concerns the gene NF1 and plexiform neurofibroma.