Differential expression analysis of Group 1 versus Group 2/3 histological neurofibromas and MPNSTs showed enrichment of Schwann cell differentiation genes (S100B, SOX10) and SUZ12 target genes (SOX18, POU3F1) in Group 2/3 compared to Group 1 tumors (Fig. 1a, Supplementary Fig. 3b–d, and Supplementary Data 3). This evidence concerns the gene SOX10 and plexiform neurofibroma.