Hierarchical clustering of RNA sequencing data from all 16 patient-derived neurofibroma or MPNST cell lines based on a consensus PRC2 target gene set comprised of 24 differentiation, early neural crest, or Ras/Raf/MEK/ERK target genes segregated PRC2-intact cell lines from PRC2-mutant cell lines (Fig. 2a). This evidence concerns the gene RAF1 and malignant peripheral nerve sheath tumor.