Moreover, the expression levels of MCT1, but not GPR81, was positively associated with NF-κB activity (Supplementary Fig. 3I, J), and NF-κB activity correlated well with intracellular lactic acid concentration in tumor-specific CTLs of KRASMUT tumors (Supplementary Fig. 3K), but not in those of KRASWT tumors (Supplementary Fig. 3L–N). The gene discussed is HCAR1; the disease is neoplasm.