At endpoint, loss of circAtxn7 did not alter the transferred cells’ exhausted phenotype and activation (Supplementary Fig. 12M), but endowed the tumors with substantially increased CTL densities (Fig. 6F) and increased the expression of perforin and CD107a, markers related to cytotoxic activity (Supplementary Fig. 12M), which correlated with improved circAtxn7-silenced T cell anti-tumor activities (Fig. 6G, H). This evidence concerns the gene PRF1 and neoplasm.