Researchers have indicated that copper induces cell death by affecting lipid acylation of the tricarboxylic acid cycle proteins.[6] Meanwhile, it was identified 7 genes conferring resistance to cuproptosis (DLD, DLAT, FDX1, LIAS, LIPT1, PDHA1, and PDHB) and 3 genes facilitating cuproptosis (CDKN2A, GLS, and MTF1).[6] Based on the available studies, it is known that oxidative stress, cytotoxicity and angiogenesis are closely related to IPF.[24–26] However, cuproptosis has not been studied in IPF. The gene discussed is CDKN2A; the disease is idiopathic pulmonary fibrosis.