A previous study has shown that IPF is associated with increased expression level of CDKN2A and induction of cell cycle arrest and cellular senescence.[32,33] And, it was found that CDKN2A was mainly located at the edge of fibroblasts exhibiting epithelial-mesenchymal transition (EMT).[34] Contrary to our results the expression level of CDKN2A was decreased in the peripheral blood of IPF patients and the fibrotic lung tissue of mice.[35,36] We believe that this may be the result of diverse species and tissue samples or differences in gene expression at specific stages of the disease. Here, CDKN2A is linked to idiopathic pulmonary fibrosis.