MRD22 syndrome (OMIM #612337) is characterized by intellectual disability (ID), growth retardation, microcephaly, corpus callosum (CC) hypoplasia, epilepsy, and dysmorphic facial features (prominent forehead, hypertelorism, flat nasal bridge, epicanthal folds, round face, and malformed low-set ears).[1] It was found that the heterozygous variant in ZBTB18 gene was the main cause of the disease. This evidence concerns the gene ZBTB18 and microcephaly.