The dysfunction of T lymphocytes can lead to a decrease in the body’s defense resistance, which brings resistance to the recovery of RA patients.[10] CD4+T lymphocytes (cluster of differentiation 4, CD4) can differentiate into different T cell subsets when stimulated by antigen-presenting cells, among them, there are T helper 1 cell, T helper 2 cell, T helper 17 cell. Here, CD4 is linked to rheumatoid arthritis.