interleukin-6 (IL-6), matrix metalloproteinase, vascular cell adhesion molecule-1 (VCAM-1), vascular endothelial growth factor (VEGF), and others.[17,18] The release of chemokines in RA patients is often caused by inflammatory cytokines, which induces a large number of inflammatory cells to migrate from the peripheral blood to the synovial membrane of the joint and destroy it, and participates in the activation and proliferation of T lymphocytes and the formation of pannus. This evidence concerns the gene VEGFA and rheumatoid arthritis.