interleukin-1 is one of the most important inflammatory cytokines.[19] Gusmao J et al found that EA treatment could significantly reduce the serum levels of IL-6 and IL-17, reduce inflammatory cell infiltration, inhibit the aggregation of osteoclasts, and reduce inflammatory parameters in RA rats with periodontitis.[20] Zhang Rui et al found that electroacupuncture can improve the infiltration of inflammatory cells in collagen-induced arthritis (CIA) rats and inhibit the positive expression of IL-1β in synovial membrane and bone tissue of CIA rats. This evidence concerns the gene IL6 and rheumatoid arthritis.