This experimental result suggests that warm acupuncture can mediate the production of immunoglobulin and interfere with the expression of related inflammatory factors.[33] Similarly, some clinical studies have found that warm acupuncture can improve the clinical joint dysfunction of patients and reduce the content of CRP, IL-1, IL-6, and TNF- in peripheral blood, which is an effective method for the treatment of active RA.[34] The effects of different moxibustion techniques on therapeutic effects should also be considered in clinical treatment. The gene discussed is IL1B; the disease is rheumatoid arthritis.