The PI3K/Akt signaling pathway plays a critical role in numerous physiological and pathological processes, including cell growth, differentiation, and proliferation.[55] Research has shown that the FXII protein can promote the occurrence of deep vein thrombosis (DVT) by inducing an inflammatory response and activating the PI3K/AKT signaling pathway.[56] IL1B and IL6 are important mediators in this inflammatory response. This evidence concerns the gene IL1B and deep vein thrombosis.