After adjustment of gender, targeted therapy and anti-angiogenic therapy, the incidence of COVID-19 pneumonia remained positively associated only with serum CRP (OR = 9.8, 95%CI: 2.2, 43.8; P = .003) and was negatively associated with lung cancer (OR = 0.3, 95%CI: 0.1, 0.7; P = .006). This evidence concerns the gene CRP and lung cancer.