In our study, we developed a signature comprising 14 PCD-related genes (BCL2A1, CASP3, CLTB, CTSK, CYP1B1, ICAM1, MMP9, PTPN2, RAC2, S100A9, TEX264, TNFAIP3, VDAC1, and ZKSCAN3) and demonstrated its ability to predict overall survival in GBM patients. Here, CASP3 is linked to glioblastoma.