In this study, we will knock down the expression of ZMIZ1 in colon cancer cells in vitro, and examine its effect on cancer cell fate decisions, as well as reveal the molecular function of ZMIZ1 as a E3 ubiquitin ligase that promotes colon cancer progression by mediating SIRT1 ubiquitination degradation. The gene discussed is ZMIZ1; the disease is malignant colon neoplasm.