To clarify whether ZMIZ regulates autophagy, proliferation and apoptosis of colon cancer cells through SIRT1, we set up two rescue experiments in which the cells of ZMIZ1 knockdown (ZMIZ-KD) were subjected to SIRT1 knockdown (SIRT-KD) or pharmacological inhibition (SIRT1 Inhibitor) (EX527, 100 nM). The gene discussed is SIRT1; the disease is malignant colon neoplasm.