In addition, we have mentioned the protective role of mitochondrial ALDH2 against oxidative stress-mediated mitochondrial dysfunction and hepatotoxicity, apoptosis/necrosis of hepatocytes and gut enterocytes, the production of DAMPs, the activation of Kupffer cells and HSCs, altered inflammation, and fibrosis, leading to cirrhosis and HCC. Here, ALDH2 is linked to hepatocellular carcinoma.