Chronic low-level inflammation induced by excess fat mass can cause immune imbalance and metabolic imbalance resulting from the deregulation of adipokines signaling, abnormal concentrations of sex hormone, and alterations in insulin and insulin-like growth factor (IGF) axis; consequently, this state may promote a favorable tumor micro-environment favorable for cancer cell growth [24, 25]. The gene discussed is IGF1; the disease is neoplasm.