CHCHD2 and cancer: Unlike previous cancer cell line studies demonstrating that mitochondrial CHCHD2 interacts with BCL-xL to inhibit apoptosis [35], CHCHD2 KO in hESCs inhibited mitochondrial cell death induced by genotoxic insults (Fig. 4), which was re-sensitized by CHCHD2 reconstitution (Fig. 6).