An abnormal increase in ROS and MDA, and a decrease in antioxidant activity (SOD and CAT) indicates that cells are suffering from oxidative stress, which is considered one of the main factors in ischemic cerebral damage and cognitive impairment (Jurcau and Simion 2020; Orellana-Urzua et al. 2020). Here, CAT is linked to Cognitive impairment.