Moreover, the overexpression of STOML2 significantly enhanced, whereas silencing STOML2 strongly compromised the ability of CRC cells to induce tubule formation of human umbilical vein endothelial cells (HUVECs) (Fig. 2e, f), suggesting STOML2 might be involved in the angiogenesis of CRC cells. This evidence concerns the gene STOML2 and colorectal carcinoma.