RAC3 and neurodevelopmental disorder: De novo pathogenic variants of RAC3 cause neurodevelopmental disorder with structural brain anomalies and dysmorphic facies (NEDBAF) (OMIM #618577) [1], whereas some de novo missense RAC1 variants with dominant-negative effect have been associated with cerebral malformations and highly variable head circumference (OMIM #617751) [2].