Lazear and colleagues indicated that WT C57BL/6 mice exhibited no morbidity or mortality due to ZIKV infection, whereas Ifnar1−/− mice that could not respond to IFNα/β were highly vulnerable to ZIKV infection, losing weight by day 5, and beginning to succumb by day 7 (64). The gene discussed is IFNAR1; the disease is Zika virus infectious disease.