Flow cytometry and immunofluorescence observation verified the significant reduction of γδ T cells expansion in the lung tissues in the anti-γδ T groups (C-Anti group and CP-Anti group) compared to the groups without γδ-TCR monoclonal antibody treatment (C group and CP group, respectively); meanwhile, compared to C group and CP group, COPD severity in C-Anti group and CP-Anti group was significantly improved, respectively. The gene discussed is CP; the disease is chronic obstructive pulmonary disease.