Mechanistically, EEBR activated the nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB)/NOD‐like receptor 3 (NLRP3) signalling pathways and promoted GSDMD cleavage in a Caspase‐1‐dependent manner, ultimately leading to pyroptosis induction in NSCLC both in vitro and in vivo. This evidence concerns the gene NLRP3 and non-small cell lung carcinoma.