The expression of NLRP3, Caspase‐1 and secretion of IL‐18 and IL‐1β were upregulated in EEBR‐treated NSCLC cells and tissues, and the EEBR‐activated NLRP3‐mediated inflammatory response was ameliorated by BAY pretreatment. This evidence concerns the gene IL18 and non-small cell lung carcinoma.