As referred to earlier, the hallmarks of Alzheimer’s disease include tau and amyloid deposition and in one study tau increase of SOD1 expression, which in animal studies, the wild-type SOD1 gene expression was found to be protective against NDG.52 It is well understood that familial amyotrophic lateral sclerosis is due to a mutation of SOD1 (Cu/Zn).76 Indeed, several of the chronic neurodegenerative pathologies of the CNS share some common features, such as inflammation, OS, synapse dysfunctions, protein misfolding and defective autophagia.4,9. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.