As referred to earlier, the hallmarks of Alzheimer’s disease include tau and amyloid deposition and in one study tau increase of SOD1 expression, which in animal studies, the wild-type SOD1 gene expression was found to be protective against NDG.52 It is well understood that familial amyotrophic lateral sclerosis is due to a mutation of SOD1 (Cu/Zn).76 Indeed, several of the chronic neurodegenerative pathologies of the CNS share some common features, such as inflammation, OS, synapse dysfunctions, protein misfolding and defective autophagia.4,9. Here, SOD1 is linked to familial amyotrophic lateral sclerosis.