SOD2 and Cognitive impairment: There is an association of the SOD2 C47T polymorphism with mild cognitive impairment associated with Alzheimer’s disease in carriers of the APOE4 allele.36 There are some inconsistencies in these findings when associating SOD2 genotypes with Alzheimer’s disease, as some researchers consider that SOD2 (rs4880) does not have a determining role in Alzheimer’s disease in the same way that SOD1 has in Parkinson’s disease.37 However, the role of the SOD2 gene in reducing OS and neutralizing ROS remains important in the pathogenesis of oxidative damage and some diseases.