NEDD4L and melanoma: In either case, our findings support future investigation into this mechanism, particularly considering the work of Kito et al., which suggests that NEDD4L overexpression is associated with progression of benign nevi to malignant melanoma (28), and gene expression profiling by Badal et al., which details upregulation of NEDD4L in malignant melanomas (Supplementary Figure S10) (31).