RUNX2 and Miyoshi myopathy: Seminal studies have shown that molecules enriched in MM-exosomes such as lncRNA RUNX2 antisense RNA 1 (RUNX2-AS1), amphiregulin, and miR-129–5p increase osteoclastogenesis by reducing RUNX2 splicing efficiency, activating the epidermal EGFR pathway, and downregulating the expression of the transcription factor Sp1, respectively[144–146].