Here, to explore the value of saliva antibody testing in patients with COVID-19, we investigated the suitability of salivary specimens for detecting IgM and IgG/IgA antibodies specific to SARS-CoV-2 in a population of COVID-19 patients with mild disease in Jeddah, Saudi Arabia, and explored associations between salivary and serum antibody levels and clinical symptoms during infection. This evidence concerns the gene CD79A and COVID-19.