The Study of Women’s Health Across the Nation with 1862 midlife multiracial women (mean age 46 years) also revealed that higher baseline total T and free androgen index (FAI) (calculated based on the measured total T and SHBG levels), as well as lower SHBG levels were associated with higher incident MetS after 5 years of follow-up. This evidence concerns the gene SHBG and metabolic syndrome.