SHBG and type 2 diabetes mellitus: For instance, a recent prospective study examining associations of hyperandrogenemia in early adulthood and the risk of abnormal glucose metabolism after 15 years of follow-up in 3280 middle-aged women in Northern Finland found that highest T and FAI quartiles and lower SHBG quartiles were related to higher odds of abnormal glucose metabolism (ie, prediabetes and type 2 diabetes mellitus) [18].