In analyses using androgens/SHBG measured at examination years 10 and 16, respectively, patterns of association of free T and SHBG, measured at year 10 (177 incident MetS cases; 23% of the sample) and year 16 (99 incident MetS cases; 18% of the sample), with incident MetS were similar to those with androgens measured from baseline, despite the shorter follow-up and fewer cases of incident MetS. The gene discussed is SHBG; the disease is metabolic syndrome.