AKT1 and breast cancer: The GO enrichment analysis conducted on the putative BC targets of JQ1 and GSK2801 revealed several major BC associated pathways such as: PI3-Akt signaling pathway [51], MAPK signaling pathway [49], serine/threonine kinase pathway [45], FoxO signaling pathway [16], [37], Notch signaling [5], p53 signaling [69] and HIF-1 signaling [79].