STAT3 and breast cancer: Interestingly, STAT3 which was among the five putative synergistic targets had the highest betweenness centrality and degree in the PPI network maps of both JQ1 and GSK2801 BC targets, was also observed as potential prognostic risk factor for overall survival in the context of BC, suggesting its potential important role in the response of BC to JQ1 and GSK2801, synergistically.