LRP1 and early-onset autosomal dominant Alzheimer disease: On the other hand, low-density lipoprotein receptor-related protein-1 (LRP1) linked to several processes, including intracellular signaling, lipid metabolism, and apoptotic clearance, as well as having a role in the regulation of the production and degradation of amyloid-β and the internalization of ApoE in Alzheimer's disease, is elevated in expression in MS lesions compared to healthy tissue, where it is thought to act as a microglia anti-inflammatory and neuroprotective stabilizer [239].