CD4 and myeloid sarcoma: People with MS also exhibited CD4+T lymphocytes in their brain lesions [59, 60] and there have been several reports of T cell dysregulation in all subtypes of MS [148], although at least as far as naïve CD4+ T cells are concerned, the alteration was particularly evident in those with rapid conversion to SPMS, where the T cell receptor (TCR) and toll-like receptor (TLR) (a costimulatory receptor of TCR-activated cells) signaling pathways were of note [149].