Several CD8+ Treg subclasses have been identified, and a comparison of MS patients and healthy individuals' blood indicates differences in Treg populations [177] where both immature and active subtypes from those with MS displayed suppression impairments following CD2 stimulation, and that natural Tregs (nTregs) from people affected with MS, were less suppressive than induced Tregs (iTregs) [178]. This evidence concerns the gene CD2 and myeloid sarcoma.