CD4+ Tregs expressing the transcription factor Foxp3 is required for peripheral immunological tolerance (regulation of autoreactive immune cells) [192]; deletion of Foxp3 on CD4+ regulatory cells leads to multiorgan autoimmunity [162] and malfunction of Tregs are related to the alteration of the Foxp3 gene. The gene discussed is FOXP3; the disease is Autoimmunity.