Notably, some DRLs, such as SNHG17, SNHG26, and SNHG16, have been previously linked to colorectal tumorigenesis and metastasis (41–43), while NCK1-DT and HOXC-AS2 expression were associated with immune cell infiltration heterogeneity (44), suggesting that DRLs may aid in predicting survival outcomes and evaluating cancer immune regulation. The gene discussed is NCK1; the disease is cancer.