Notably, some DRLs, such as SNHG17, SNHG26, and SNHG16, have been previously linked to colorectal tumorigenesis and metastasis (41–43), while NCK1-DT and HOXC-AS2 expression were associated with immune cell infiltration heterogeneity (44), suggesting that DRLs may aid in predicting survival outcomes and evaluating cancer immune regulation. This evidence concerns the gene SNHG16 and medical procedure.