In this study, we used umbilical cord MSCs and conditioned medium to treat acetic acid-induced gastric ulcers in a mouse model and found that they can effectively reduce ulcer area, possibly promoting gastric epithelial cell proliferation through the Erk/Akt pathway, effectively reducing cell apoptosis through TRIM29, and promoting ulcer basal angiogenesis. Here, TRIM29 is linked to ulcer disease.