VEGF overexpression has been reported in solid tumors, therefore VEGF is considered as a potential marker for cancer [74].VEGF-A, angiogenic multifunctional mediator, binds to extracellular domain of VEGFR2 and transduce the responses of VEGF in ECs including ECs survival and proliferation, migration, permeability, and formation of capillary lumen, thus orchestrating the vasculature of cancer. The gene discussed is KDR; the disease is cancer.