CXCL8 and neoplasm: ELR+ includes CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8, which binds to the receptor CXCR2, that are overexpressed in microvascular ECs and tumor vessels, and enhances angiogenesis [107].