The expression of CCR4, CXCR3, CCR2, and CCR8 was higher in highly invasive oral cancer cell lines (SCC-25, CAL-27, and FaDu) than in the less aggressive cell line (HSC-2), whereas CCL19 and P2RY14 expression showed the opposite trend (Fig. 8A, 8B). The gene discussed is CCR8; the disease is lip and oral cavity carcinoma.