After excluding cancers with a small sample size (Figure S1B), we have observed a significant increase in the total protein expression of CDCA5 in primary tissues of clear cell RCC, colon cancer, head and neck squamous carcinoma, ovarian cancer, lung adenocarcinoma, and UCEC compared to normal tissues based on the CPTAC dataset. Here, CDCA5 is linked to malignant colon neoplasm.