Furthermore, ATP enzyme inhibitor 1 (IF1), a physiological inhibitor of ATP synthase, is overexpressed in a significant proportion of malignancies that contribute to metabolic alternations and tumor development, and the overexpression of mitochondrial IF1 prevents metastatic disease in CRC through promoting anoikis and neoplasm infiltration in NK cells21. The gene discussed is ATP5IF1; the disease is colorectal carcinoma.