In addition to the AKT pathway, other signaling pathways have also been reported to be involved in PDIA3-mediated biological functions in cancers, such as STAT3 signaling [28], EGFR signaling [32], 1alpha, 25-dihydroxy vitamin D3 [1,25(OH)2D3]-mediated pathway [33] and mTOR signaling [31]. The gene discussed is STAT3; the disease is cancer.