The recent study found that N6-methyladenosine (m6A) demethylase AlkB homolog 5 (ALKBH5) interacts with PDL1 mRNA, leading to the inhibition of m6 modification in the 3’ untranslated regions (3’UTR) region of m6PDL1 mRNA, and promoting PDL1 expression in ICCA [55]. This evidence concerns the gene CD274 and infantile convulsions and choreoathetosis.