The mechanisms mediating the effect ofADRA1A in behavior regulation are poorly understood, butit is known that long-term ADRA1A stimulation mitigatesdepression-like behavior and anxiety, and tricyclic antidepressantsincrease the ADRA1A receptor density in theforebrain of rodents (Deupree et al., 2007; Doze et al.,2009, 2011). Here, ADRA1A is linked to Anxiety.