Nf1 and Trp53 alterations were present in both models, but neither model exhibited Idh1/2, Atrx, Braf, H3f3a mutations nor copy number alterations of Pten, Egfr, Nf1, or Rb1, all of which are commonly associated with huGBM and astrocytoma. Here, PTEN is linked to astrocytoma (excluding glioblastoma).