RH3, a metabolite of the ginoside Rg5, can decrease the production of SLC7A11 and GPX4 by disrupting the Stat3/p53/NRF2 signaling pathway, resulting in GSH depletion and the buildup of iron, lipid ROS, and MDA, ultimately leading to ferroptosis of colorectal cancer cells [86]. Here, GPX4 is linked to colorectal cancer.