Senescent tubular cells have strong impacts on surrounding cells by secreting various SASP molecules, including inflammatory cytokines, chemokines, growth factors and extracellular matrix remodelling factors, such as TGF‐β, plasminogen activator inhibitor‐1 (PAI‐1), monocyte chemoattractant protein‐1 (MCP‐1), interleukin 1α (IL‐1α) and interleukin‐6 (IL‐6), etc.47, 48, 49, 50These suggest that senescent tubular cells play a crucial role in the development of renal fibrosis. This evidence concerns the gene IL6 and renal fibrosis.