Notably, in one of the previous studies (Pijacka et al., 2016), researchers were trying to reveal a novel treatment target for hypertension so as to address the drug resistance issue of the current hypertension treatment: they discovered that the expression of P2X3 mRNA was significantly increased in petrosal sensory neurons in spontaneous hypertensive rats (SHR). Here, P2RX3 is linked to Hypertension.