Research conducted on leukocytes and SCs from ALS patients and SOD1 mouse models has demonstrated a significant inflammatory component in disease pathobiology; peripheral blood cell counts of natural killer cells, granulocytes, CD3+, CD4+, CD8+ and CD3+CD56+T cells were all shown to increase in patients with ALS [28]. This evidence concerns the gene NCAM1 and amyotrophic lateral sclerosis.